The collaboration between SeaStar Medical and the Autonomous Reanimation and Evacuation (AREVA) Research Institute, supported by a Department of Defense (DoD) grant, marks a pivotal step in addressing the critical need for effective treatments against severe burns, inhalation injuries, and septicemia. These conditions often lead to destructive hyperinflammation, causing organ failure and high mortality rates. The grant, part of the 2024 Military Burn Research Program (MBRP), funds a three-year study starting July 2025, focusing on SeaStar Medical’s Selective Cytopheretic Device (SCD) therapy. This innovative approach aims to modify the body’s immune response by treating blood outside the body, neutralizing overactive immune cells to reduce inflammation.

The SCD therapy, used alongside continuous renal replacement therapy (CRRT), is designed to support organ recovery, potentially reducing the need for lifelong dialysis and saving lives. Dr. Andriy Batchinsky, principal investigator at AREVA, highlights the study’s potential to significantly impact patient outcomes, especially for those with infection- and trauma-related organ failures. The Geneva Foundation will provide administrative support for the research conducted at the AREVA Institute in San Antonio, Texas.

SeaStar Medical’s SCD therapy has already shown promise in treating pediatric acute kidney injury (AKI), with FDA approval in February 2024 and clinical trials demonstrating reduced mortality rates and dialysis duration. The ongoing adult AKI trial aims to further validate the therapy’s efficacy and safety. The SCD therapy’s organ and disease-agnostic nature suggests broad applications across various acute and chronic conditions, offering hope for patients with limited treatment options.

This research not only underscores the DoD’s confidence in AREVA’s capabilities and the SCD therapy’s potential but also represents a critical advancement in medical science for treating severe trauma and infection. The study’s outcomes could revolutionize care for critically wounded service members and civilians alike, addressing a long-standing challenge in trauma and burn care.

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